Renal excretion of unchanged modafinil usually accounts for less than 10% of the oral dose. This means that when modafinil is taken by mouth, that's the only permitted route of administration, fewer than 10% from the drug is removed from the body from the urine without having being metabolized through the liver or other organs.

modafinil will boost the level or outcome of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Small/Significance Unfamiliar. Net effect on pantoprazole actions not known resulting from opposing consequences of CYP450 enzymes; keep track of

nefazodone will raise the amount or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

A few early animal research have reported that modafinil also partly activates the dopamine D2 receptor, and should encourage wakefulness by stimulating the discharge of dopamine through the brain (specifically during the nucleus accumbens) [12, 13].

modafinil will lessen the extent or influence of iobenguane I 131 by Other (see comment). Keep away from or Use Alternate Drug. Dependant on the mechanism of action of iobenguane, medication that decrease catecholamine uptake or that deplete catecholamine merchants may well interfere with iobenguane uptake into cells, and therefore, reduce iobenguane efficacy.

This medication might result in serious pores and skin reactions. They can materialize months to months following commencing the medicine. Get in touch with your well being treatment service provider without delay should you discover fevers or flu-like symptoms by using a rash.

Worries are already raised about the growing utilization of modafinil as a "smart drug" or cognitive enhancer among the healthy individuals who utilize it While using the goal to improve focus and memory.[218][219] In 2003, modafinil sales were skyrocketing, with a few gurus worried that it experienced turn into a tempting decide on-me-up for persons hunting for an extra edge inside of a productiveness-obsessed Modern society.

Substantial clinical exploration has not shown drug tolerance as a typical adverse influence, Despite therapeutic use extending as many as 40 weeks.

Keep away from coadministration of ganaxolone with reasonable or sturdy CYP3A4 inducers. If coadministration unavoidable, contemplate rising ganaxolone dose; even so, don't exceed maximum day by day website dose for body weight.

On top of that, Cephalon entered agreements with numerous generic drug brands to delay the sale of generic modafinil from the US.

Modafinil is applied to treat extreme sleepiness brought on by slumber apnea, narcolepsy, or shift get the job done sleep disorder.

The next sections describe some of the exploration which has been accomplished around the potential medical purposes of modafinil. Nonetheless, these results are all however quite preliminary, and also have not strongly recognized a scientific situation for making use of modafinil for these works by using or situations.

enzalutamide will minimize the level or result of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

etravirine will lower the level or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.